Evaluation of D3 Receptor Occupancy Using FLUORTRIOPRIDE ([18F]FTP) PET/CT
Status:
Active, not recruiting
Trial end date:
2022-06-01
Target enrollment:
Participant gender:
Summary
Preclinical work suggests that D3 dopamine receptors may be important in the study of the
pathophysiology of affective disorders, psychotic disorders and addiction. D3 receptors may
also play a role in dystonia, Parkinson's disease and response to treatment of these
disorders. However, there has been a lack of specific radioligands for imaging D3 receptors.
This proposed protocol will evaluate the uptake of [18F]FTP as a more specific in vivo
measure of D3 receptor binding in the brain in healthy volunteers subjects after injection of
lorazepam vs placebo, and in cocaine-dependent subjects. Test-retest scans will evaluate the
variability of [18F]FTP uptake measures in both healthy volunteer subjects and
cocaine-dependent subjects.